Designed Synthesis of 1, 3, 4-Oxadiazole Derivatives Promoted By Grinding Method

The most straight forward synthetic route was involved preparation of 2-(5-bromo-6-methylpyridin-3-yl)-5-phenyl-1, 3, 4-oxadiazole (5a-5h) from the cyclodehydration of 2-(5-bromo-6-methylpyridin-3-yl)-5-phenyl-1, 3, 4-oxadiazole (5a-5h) from the cyclodehydration of 5-bromo-6-methylnicotinohydrazide (3) with substituted aromatic aldehyde(4) which typically requires harsh reagents such as I₂/K₂CO₃ in followed by grinding method . The intermediate (3) can be obtained from the compound (2) with hydrazine hydrate and an intermediate (2) was prepared by the reaction between 5-bromo-6-methylnicotic acid with thionyl chloride in non-polar medium. The required derivatives can be evaluated by advanced spectral analysis such as ¹HNMR, ¹³CNMR and LCMS and the structural derivatives determined by elemental analysis. The biological activity of the titled analogous examined against antimicrobial studies.