Solubility Enhancement of Azithromycin and Indomethacin in Aqueous Single/Binary Micellar system

Drug is a chemical compound which is use to diagnose, cure, treat, or prevent diseases. Azithromycin and Indomethacin belongs to class 2 drugs which are used for the treatment of various severe ailments. Both the drug are poorly Soluble in water and has poor bioavailability. So, these poor bioavailability can overcome by enhancing its solubility. Complexing of drug with different type of surfactant is possible to increase the solubility and dissolution rate in gastro-intestinal tract. In the Present work Sodium dodecyl Sulfate and Cetyltrimethyl ammonium bromide were used. The Main Purpose of this project was to increase drug solubility in Single/Binary Surfactants. The Absorbance of drugs was characterized by UV Spectrophotometer. The use of conventional surfactants can significantly increase the solubility of these drugs in aqueous solution without destruction of drug. . Enhancement of drug solubility gives more efficacies in Aqueous Self Assembly solution. From the result it is found that Surfactant can also act as carrier and solubility of Azithromycin and Indomethacin can also increase in aqueous solution as well.